Montelukast moderately decreased asthma symptoms in children with persistent asthma
نویسندگان
چکیده
منابع مشابه
Montelukast moderately decreased asthma symptoms in children with persistent asthma.
Patients 689 children who were 2 to 5 years of age (mean age 4 y, 59% boys, 56% white), had > 3 episodes of asthma symptoms in the previous year, had a total asthma symptom score > 1 (of 24) for > 8 days during the 2 week placebo baseline period, and used â agonists for > 8 days during the placebo baseline period. Exclusion criteria included asthma intubation and emergency department treatment ...
متن کاملMontelukast as monotherapy in children with mild persistent asthma.
The cysteinyl leukotrienes cause bronchoconstriction, increased mucus production and airway inflammation, three major features of asthma. Several randomized controlled trials have shown the efficacy of leukotriene receptor antagonists for improving asthma outcomes. The drug is favored for treating childhood asthma, where poor compliance with inhalation therapy is a therapeutic challenge. To ass...
متن کاملMarginal utility of montelukast for persistent asthma.
BACKGROUND The efficacy of a new pharmacologic agent for asthma, in this instance the leukotriene receptor antagonist montelukast, is determined in controlled trials in research subjects. The utility of a new drug is determined by multiple uncontrollable factors in individual patients. OBJECTIVE To assess the utility of montelukast in the management of persistent asthma. DESIGN Observationa...
متن کاملDetermine Efficacy of a Short Course of Montelukast in Children with Intermittent Asthma and Viral Infection
Introduction Mild intermittent asthma is common in children and viral infections are responsible for the majority of exacerbations. As leukotrienes are potent inflammatory mediators, some studies have shown that Montelukast, a leukotriene receptor antagonist, may be effective on reduction of asthma symptom. To determine whether a short course of Montelukast in asthmatic children with common col...
متن کاملComparative efficacy and safety of low-dose fluticasone propionate and montelukast in children with persistent asthma.
OBJECTIVE To evaluate efficacy, safety, health outcomes, and cost-effectiveness of fluticasone propionate (FP) versus montelukast (MON) in 342 children (6 to 12 years of age) with persistent asthma. STUDY DESIGN Randomized, double-blind, 12-week study of treatment with FP inhalation powder 50 mug twice daily or MON chewable 5 mg once daily for 12 weeks. RESULTS Compared with MON, FP signifi...
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ژورنال
عنوان ژورنال: Evidence-Based Medicine
سال: 2002
ISSN: 1356-5524
DOI: 10.1136/ebm.7.3.77